Sam Prendergast will start for Ireland against Argentina, after recovering from a wrist injury.
Head coach Andy Farrell has also given a first test start to Connacht’s Sean Jansen having made his debut during the summer.
Sam Illo is also in line for his home debut at Aviva Stadium off the bench.
Hugo Keenan starts at full-back with Robert Baloucoune and Mack Hansen, who will make his first Ireland appearance in a year, on the wings.
Stuart McCloskey partners Robbie Henshaw in the Ireland midfield, as Craig Casey and Sam Prendergast link up as scrum and out-half pairing.
In the pack, Andrew Porter, Captain Dan Sheehan and Tadhg Furlong make up the front row, with Joe McCarthy and Tadhg Beirne in the second row.
Ryan Baird is named at blindside flanker, Nick Timoney is at openside and Jansen completes the starting team at number eight.
